Retinoic acid-induced embryopathy of the mouse inner ear
| Autor: | Thomas R. Van De Water, V. Galinovic-Schwartz, Dorothy A. Frenz, Wei Liu |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vestibular system
Embryology medicine.medical_specialty animal structures Embryonic age Health Toxicology and Mutagenesis Embryogenesis Retinoic acid Morphogenesis Biology Toxicology Embryonic stem cell Teratology chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine embryonic structures medicine Inner ear sense organs Developmental Biology |
| Zdroj: | Teratology. 53:292-303 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/(sici)1096-9926(199605)53:5<292::aid-tera3>3.0.co;2-3 |
| Popis: | Retinoic acid (RA) is an active metabolite of vitamin A that is teratogenic when present in excess during mammalian embryogenesis. We have investigated the effect of embryonic exposure to nonphysiological levels of all-trans RA on the development of the mouse inner ear. Dysmorphogenesis of both vestibular and auditory portions of the inner ear, and abnormal formation of the surrounding capsule are produced by exposure to teratogenic levels of RA at an embryonic age of 9 days (E9). There was no observable teratogenic effect of RA when administered at earlier (i.e., E7 or E8) or later (i.e., E10) stages of otic morphogenesis. We hypothesize that exposure to high levels of RA during a critical period of early otic morphogenesis interferes with the inductive tissue interactions required for inner ear development. |
| Databáze: | OpenAIRE |
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