Asymmetric reduction of ketones by biocatalysis using medlar (Mespilus germanicaL) fruit grown in Algeria

Autor:	Saoussen Zeror, Manhel Bennamane, Louisa Aribi-Zouioueche
Rok vydání:	2014
Předmět:	biology Aqueous medium biology.organism_classification Biochemistry Catalysis chemistry.chemical_compound chemistry Biocatalysis Furan Tetralone Thiophene Organic chemistry Mespilus Enantiomeric excess Biotechnology
Zdroj:	Biocatalysis and Biotransformation. 32:327-332
ISSN:	1029-2446 1024-2422
DOI:	10.3109/10242422.2014.978305
Popis:	The biocatalytic reduction of ketones was performed using medlar fruit (Mespilus germanica L), which is grown in large amounts in Algeria. Experiments were performed using aqueous medium with fresh medlar. Prochiral heteroaryl ketones containing furan, thiophene, chroman, and thiochroman moieties were reduced with enantiomeric excess (ee) of up to 98%. High enantioselectivities have been observed especially for the bioreduction of tetralone 4 and thiochromanone 5 with ee of 89% and 98%, respectively. Bioreduction using different parts of medlar indicate that chromanone 6 was reduced with good asymmetric inductions 77% < ee < 85% whichever part of fruit was employed (whole, flesh, or juice) and medlar juice exhibited the best activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::09f72c08825a3fdde6cbc02da12a89e5 https://doi.org/10.3109/10242422.2014.978305 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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