ANTICYTOSKELETAL DRUGS AND TIME CULTURE EFFECTS UPON THE MECHANICAL BEHAVIOR OF DERMAL EQUIVALENT TISSUE SUBMITTED TO UNCONFINED COMPRESSION LOADING

Autor:	Salah Ramtani, Didier Geiger
Rok vydání:	2008
Předmět:	Materials science medicine.medical_treatment Biomedical Engineering Biomaterial Human skin Matrix (biology) Strain rate Viscoelasticity Extracellular matrix medicine.anatomical_structure Dermis medicine Skin grafting Biomedical engineering
Zdroj:	Journal of Mechanics in Medicine and Biology. :339-352
ISSN:	1793-6810 0219-5194
DOI:	10.1142/s0219519408002735
Popis:	The dermal equivalent (DE), a dermis substitute consisting of human skin fibroblasts growing into a three-dimensional collagen matrix, is extensively used in many applications: wound-healing response, pharmacological studies, skin grafting, fibroblast proliferation and migration, extracellular matrix remodeling, and efficacy of cosmetic products. The widespread growth of numerical modeling in biomechanical research has placed a heightened emphasis on accurate material property data for soft biological tissues, in particular for equivalent dermis which has not been so thoroughly investigated. Under unconfined compression loading, the effects of the strain rate, time culture, and cytoskeleton-disrupting agents are experimentally investigated. In order to model the observed mechanical behavior of the DE under the above conditions, the internal state variable approach is adopted for finite deformation viscoelasticity and the optimized material parameters are identified with respect to the stated thermodynamic restriction (i.e. positive viscous dissipation).
Databáze:	OpenAIRE
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