| Popis: |
A number of agents have entered clinical trials in recent years. Spiroindolines have been of interest because of their inhibition of ATP4ase and disruption of sodium ion concentrations within the parasite cell. Dihydroisoquinolones, aminopyrazole, and pyrazoleamides have also been discovered that act against this target. Imidazolopiperazines, imidazopyridazines, and pyrazolopyridines have been discovered that inhibit protein transport and localization. The translation elongation factor 2 involved in Plasmodium protein translation is the target for a number of quinolines. The antimalarial activity of MK-4815 and NCGC00100599 have also been of interest. Finally, agents that inhibit choline transport have been shown to be potent antimalarial agents. |
