271 REDUCTION IN PERINATAL SURVIVAL OF PROGENY OF CAFFEINE TREATED MALE RATS
| Autor: | John M. Peterson, Justin M. Joffe, Sue M Smith, Lester F. Soyka |
|---|---|
| Rok vydání: | 1978 |
| Předmět: | |
| Zdroj: | Pediatric Research. 12:409-409 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-197804001-00276 |
| Popis: | Twenty male Sprague-Dawley rats were injected s.c. with caffeine in sterile water, 25 mg/kg at 0900 and 1600 hrs for four days. Each was then caged with a proestrus female from 1600 - 0900 hrs following which seventeen had sperm present in vaginal smears. Only 12 delivered, 127 live and 4 dead pups, at 21 days. Live born litter size ranged from 2 - 15, mean 10.6 ± 1.4 (S.E.M.). Sex ratio favored males 1.18. Birth weights were: males 6.20 ± 0.09; females 6.23 ± 0.08 g and weaning weights 47.0 ± 1.2 and 45.8 ± 1.0 respectively. Weights of females were equivalent to controls whereas those of males were decreased. In six large studies birth weights of males have always been significantly greater than that of females. Weaning weights were comparable to controls. Deaths before weaning averaged 37%. Death rates in 2,611 offspring of controls in our laboratory ranged from 2 - 10%, averaging 8%. Three litters had no deaths and an equal number had no survivors. Death rates for males and females were equivalent. Most deaths occurred between 6 - 12 postnatal days. No obvious anomalies were noted to account for the high death rate. These data are analogous to our previous findings with progeny of male rats administered methadone prior to mating and suggest that paternal drug exposure may be a crucial determinant of fetal outcome. Supported by NIDA 01160. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|