HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone

Autor:	Mirjam Hemmelmann, Kaloian Koynov, Rudolf Zentel, Matthias Barz, Mareli Allmeroth, Christiane Knoth, Frank Rösch, Dorothea Moderegger, Ulrich Schmitt, Christoph Hiemke
Rok vydání:	2011
Předmět:	Materials science Polymers and Plastics Stereochemistry Organic Chemistry Radical polymerization Motor behaviour Domperidone Amphiphile Materials Chemistry medicine Copolymer Biophysics Cns activity medicine.drug Amphiphilic copolymer
Zdroj:	Macromolecular Rapid Communications. 32:712-717
ISSN:	1022-1336
DOI:	10.1002/marc.201000810
Popis:	In this study we give evidence that domperidone encapsulated into amphiphilic p(HPMA)-co-p(laurylmethacrylate) (LMA) copolymer aggregates is able to cross the blood-brain barrier, since it affected motor behaviour in animals, which is a sensitive measure for CNS actions. Carefully designed copolymers based on the clinically approved p(HPMA) were selected and synthesized by a combination of controlled radical polymerization and post-polymerization modification. The hydrodynamic radii (R(h) ) of amphiphilic p(HPMA)-co-p(LMA) alone and loaded with domperidone were determined by fluorescence correlation spectroscopy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::09d1a1519f32be8706f9987ef28527f1 https://doi.org/10.1002/marc.201000810 Zobrazit plný text záznamu Plný text