Sequential injection technique for determination of phenoxybenzamine hydrochloride and metoclopramide in pharmaceutical formulations

Autor:	Suling Feng, Jing Fan, Zhijun Guo
Rok vydání:	2009
Předmět:	Detection limit Sequential injection analysis Chromatography Metoclopramide Hydrochloric acid Phenoxybenzamine Hydrochloride Pharmacology Analytical Chemistry chemistry.chemical_compound Sequential injection chemistry Linear range medicine Sodium nitrite medicine.drug
Zdroj:	Journal of Analytical Chemistry. 64:847-852
ISSN:	1608-3199 1061-9348
DOI:	10.1134/s1061934809080139
Popis:	A sequential injection analysis (SIA) system is described for the determination of phenoxybenzamine hydrochloride and metoclopramide using spectrophotometer as detector. The method is based on the detection of an unstable red intermediate compound resulting from the reaction of phenoxybenzamine hydrochloride or metoclopramide with the diazotizating product of p-phenylenediamine with sodium nitrite in hydrochloric acid medium. The sampling frequency is 69 h−1 and 75 h−1 for phenoxybenzamine hydrochloride and metoclopramide, respectively. The linear range is 10–400 μg/mL for phenoxybenzamine hydrochloride with a detection limit of 0.081 μg/mL and 20–250 μg/mL for metoclopramide with a detection limit of 0.034 μg/mL. The RSD is 1.01 and 0.45% for phenoxybenzamine hydrochloride and metoclopramide, respectively. The proposed methods were used to determine phenoxybenzamine hydrochloride and metoclopramide in pharmaceuticals. The results are compared with those obtained by pharmacopoeia method.
Databáze:	OpenAIRE
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