Enantioselective effect of cysteine functionalized mesoporous silica nanoparticles in U87 MG and GM08680 human cells and Staphylococcus aureus bacteria
| Autor: | Yurii K. Gun'ko, Carmela Cela, Marina Martínez-Carmona, Vera Kuznetsova, Joan A. Geoghegan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
organic chemicals Biomolecule technology industry and agriculture Biomedical Engineering Enantioselective synthesis Nanoparticle 02 engineering and technology General Chemistry General Medicine Mesoporous silica 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Nanomaterials chemistry General Materials Science Enantiomer 0210 nano-technology Chirality (chemistry) Cysteine |
| Zdroj: | Journal of Materials Chemistry B. 9:3544-3553 |
| ISSN: | 2050-7518 2050-750X |
| Popis: | Chirality is a fundamental phenomenon in biological systems, since most of the biomolecules and biological components and species are chiral and therefore recognize and respond differently depending on the enantiomer present. With increasing research into the use of nanomaterials for biomedical purposes, it is essential to understand the role that chirality of nanoparticles plays at the cellular level. Here, the chiral cysteine functionalization of mesoporous silica nanoparticles has been shown to broadly affect its interaction with U87 MG human glioblastoma cell, healthy human fibroblast (GM08680) and methicillin-resistant S. aureus bacteria. We believe that this research is important to further advancement of nano-biotechnology. |
| Databáze: | OpenAIRE |
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