Uterine junctional zone thickness in infertile women evaluated by MRI

Autor: Leen Wijnen, Willem Ombelet, L. J. Meylaerts, Marjan Vandersteen, Marc Bazot
Rok vydání: 2016
Předmět:
Zdroj: Journal of Magnetic Resonance Imaging. 45:926-936
ISSN: 1053-1807
DOI: 10.1002/jmri.25422
Popis: Purpose To prospectively evaluate and compare the junctional zone (JZ) and outer myometrial thickness in infertile and healthy nulliparous women at different locations in the uterine wall during the menstrual cycle by magnetic resonance imaging (MRI). Materials and Methods We performed pelvic 1.5T MRI (T2-weighted turbo spin echo sequences) on 28 infertile women: 5 with infertility of unknown origin, 12 anovulating, and 11 on ovarian stimulation therapy (mean age 28.5, 30.8, and 29.3 years, respectively); and a control group consisting of 18 healthy nulliparous volunteers (mean age 26.4 years). The women with unknown infertility origin and the control group underwent MRI investigations during their follicular, ovulatory, and luteal phase. The JZ and outer myometrial thicknesses were measured at six locations in the uterine wall: anterior and posterior wall of the isthmus, midcorpus, and fundus. Results The JZ in the anovulating women at the posterior wall of the isthmus (4.2 mm) was significantly thicker compared to the control group (3.2, 3.0, and 2.9 mm, in respectively the three menstrual phases) (P = 0.027). The outer myometrium in the anovulating women was significantly thicker at all measured locations (average 11.5 mm) in comparison to the control group (8.1, 8.0, and 8.5 mm, in respectively the three menstrual phases) (P < 0.050). The infertile women on ovarian stimulation therapy showed a significantly thicker outer myometrium at the anterior wall (isthmus, midcorpus, and fundus) (P < 0.050). Conclusion The results indicate that a thickened JZ, and especially a thickened outer myometrium, might be associated with infertility. J. Magn. Reson. Imaging 2016
Databáze: OpenAIRE
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