Case report: Unusual Interaction Between Voriconazole and Ritonavir/Lopinavir in a COVID-19 Patient Due to CYP2C19 Gene Polymorphism

Autor:	Lifang Duan, Lei Huang, Wei-Xing Zhang, Qilin Pang
Rok vydání:	2020
Předmět:	Voriconazole Coronavirus disease 2019 (COVID-19) biology business.industry virus diseases Cytochrome P450 Lopinavir CYP2C19 Pharmacology immune system diseases medicine biology.protein Ritonavir Gene polymorphism business medicine.drug
DOI:	10.22541/au.160098501.14034083
Popis:	Drug–drug interactions may be a serious issue for COVID-19-infected patients needed kinds of conminant medications. voriconazole and lopinavir/ritonavir were involved in interaction with cytochrome P450 enzymes, Therefore, coadministration of voriconazole and lopinavir/ritonavir is estimated to interfere the effect of voriconazole. However, the gene polymorphisms make these interactions more complicating.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::09baabb4448b40f376f43656844866f1 https://doi.org/10.22541/au.160098501.14034083 Zobrazit plný text záznamu