| Popis: |
The oxazolidinone compound E3709, which contains a 4-pyridyl group, was found to be more active in vitro than other members of this series, such as DuP 721. MIC 90 for staphylococci (including methicillin-resistant isolates), streptococci (including Enterococcus faecalis), Clostridia , and diphtheroids was μ g/ml. Haemophilus influenzae, Moraxella catarrhalis and Bacteroides fragilis were less susceptible, with an MIC 90 between 2 and 8 μg/ml. E3709 MICs of Gram-negative species ranged from 100 to >100 μg/ml. At a concentration of 10 μg/ml, E3709 was bactericidal for selected Grampositive species. A postantibiotic effect of 3 hr was observed against staphylococci. Resistance to E3709 was not detected. |
