| Autor: |
Robin M. Murray, Padraig Wright, P.T. Donaldson, P. Laing |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Psychiatry, Psychoimmunology, and Viruses ISBN: 9783211832493 |
| DOI: |
10.1007/978-3-7091-6404-4_10 |
| Popis: |
Disease discordance of 50% in monozygotic twins implicates genetic and environmental factors in the aetiology of schizophrenia. Autoimmune diseases are HLA associated and are thought to occur when a genetically predisposed individual is exposed to an essential, probably viral, environmental trigger. We have reported an excess of autoimmune diseases in the first degree relatives of schizophrenic patients, an excess of second trimester influenza infections in the mothers of schizophrenic patients, and a deficiency of HLA DRB1*O4 alleles in the mothers of schizophrenic patients and in schizophrenic patients themselves. We have therefore hypothesised that maternal immunogenetic predisposition interacts with the influenza virus to cause neurodevelopmental lesions which manifest in adulthood as schizophrenia. Our work raises the possibility of an (immuno)genetic predisposition to schizophrenia at pedigree, maternal, and proband level. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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