The synthesis of 2-(alkylthio)- and 2-(arylthio)-3-cyanothiophenes. The nucleophilic displacement of the alkylsulfinyl group by thiols

Autor:	H. C. Wals, H. Dolman, J. M. Luteijn
Rok vydání:	1988
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Sulfoxide Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Nucleophile Group (periodic table) Drug Discovery Nucleophilic substitution Thiol Alkyl
Zdroj:	Tetrahedron. 44:5921-5928
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)81450-2
Popis:	The nucleophilic substitution of activated 2-(alkylsulfinyl)thiophenes with alkyl- or arylmercaptans gives the corresponding 2-(alkylthio)- or 2-(arylthio)- substituted thiophenes. When thiolate anion is used instead of thiol, sulfoxide reduction is the main reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::09af31ecc9beb90c193d7ea1b0e3eabd https://doi.org/10.1016/s0040-4020(01)81450-2 Zobrazit plný text záznamu