P264 - Extra-intestinal manifestations in IBD are associated with specific mucosal inflammatory genes expression profiles
| Autor: | L. Barbarii, S. Gologan, D. Iancu, Razvan Iacob, S. Iobagiu, A. Catuneanu, Mircea Diculescu, Liana Gheorghe, Bogdan Cotruta, Cristian Gheorghe, Speranta Iacob, C. Baceanu |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Thiopurine methyltransferase biology business.industry Population Gastroenterology Mucous membrane General Medicine medicine.disease Inflammatory bowel disease medicine.anatomical_structure Internal medicine Cohort medicine biology.protein Allele Colitis education business Irritable bowel syndrome |
| Zdroj: | Journal of Crohn's and Colitis. 3:S115 |
| ISSN: | 1873-9946 |
| DOI: | 10.1016/s1873-9946(09)60291-9 |
| Popis: | s of the 4th Congress of ECCO the European Crohn’s and Colitis Organisation S115 Results: Among the patients enrolled in the study, 8 patients were heterozygous for a variant TPMT allele (2.6%), while the rest had a wild-type gene. Frequencies of deficient alleles TPMT*2, TPMT*3A, and TPMT*3C were 0.6%, 0.6% and 2.6%. No TPMT *3B allele was found. Conclusion: TPMT*3C was the most frequently ocurring nonfunctional TPMT allele in Croatian IBD population. Although predominant allele is obvious in this set of patients, regarding to relatively lower frequency of TPMT polymorphisms we need further investigation in cohort of healthy controls prior definite conclusion about benefit of pharmacogenetically guided dosing |
| Databáze: | OpenAIRE |
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