Steroid compounds from the Far East starfish Pteraster obscurus and the ophiura Asteronyx loveni

Autor:	E. V. Levina, Pavel S. Dmitrenok, A I Kalinovskiĭ
Rok vydání:	2007
Předmět:	Asteronyx loveni biology Stereochemistry medicine.medical_treatment Organic Chemistry Starfish Pteraster obscurus biology.organism_classification Biochemistry Sodium salt Steroid chemistry.chemical_compound Sulfation chemistry medicine Sulfate
Zdroj:	Russian Journal of Bioorganic Chemistry. 33:341-346
ISSN:	1573-9163 1068-1620
DOI:	10.1134/s1068162007030119
Popis:	Seven sulfated polyhydroxysteroids were isolated from the Far East starfish Pteraster obscurus and the ophiura (snake star) Asteronyx loveni (collected in the Sea of Okhotsk) and characterized: disodium and sodium salts of (20R)-24-methyl-2beta-hydroxycholesta-5,24(28)-diene-3alpha,21-diyl disulfate, (20R)-5alpha-cholestane-3beta,21-diyl disulfate, (20R)-3beta-hydroxy-5alpha-cholestan-21-yl sulfate, (20R)-cholest-5-ene-3beta,21-diyl disulfate, (20R)-2beta-hydroxycholest-5-ene-3alpha,21-diyl disulfate, (20R)-cholest-5-en-3beta-yl sulfate, and (20R)-5alpha-cholestan-3beta-yl sulfate. The first four compounds turned out to be new, whereas the others were identical to the known compounds. Structures of the isolated steroids were identified by two-dimensional NMR spectroscopy and other physicochemical methods. The compounds isolated from starfish are structurally similar to typical ophiuroid metabolites, which support the opinion of some taxonomists that starfish and ophiuroids are phylogenetically related classes.
Databáze:	OpenAIRE
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