LOC389641 promotes papillary thyroid cancer progression by regulating the EMT pathway
| Autor: | Jinmiao Qu, Ruida Quan, Xiaohua Zhang, Chen Zheng, Jialiang Wen, Bangyi Lin, Cheng-Ze Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system diseases business.industry Biochemistry (medical) Clinical Biochemistry Cancer medicine.disease Malignancy Long non-coding RNA Papillary thyroid cancer Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Drug Discovery medicine Cancer research Biomarker (medicine) Epithelial–mesenchymal transition business Thyroid cancer |
| Zdroj: | Biomarkers in Medicine. 14:969-980 |
| ISSN: | 1752-0371 1752-0363 |
| Popis: | Aim: Thyroid cancer (TC) is one of the most common types of endocrine malignancy and poses a significant challenge to human health. The long noncoding RNA 389641 ( LOC389641) has been found to be associated with many types of cancer. However, the function of LOC389641 in papillary TC (PTC) remains unknown. Our aim is to explore LOC389641 expression and its role in TC. Materials & methods: The function of LOC389641 was determined by colony formation, migration and invasion assays in PTC. Western blot assays were performed to determine the biomarker of epithelial–mesenchymal transition. Results: In this study, we show that LOC389641 is involved in PTC, which suggests that it may be a target for TC therapies. |
| Databáze: | OpenAIRE |
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