Biological responses to silicon and nitrogen-rich PVD silicon nitride coatings
| Autor: | Ryan M. Bock, Narisato Kanamura, Bal Bhajanjit Singh, Toshiro Yamamoto, Francesco Boschetto, Tetsuya Adachi, E.N. Jones, Giuseppe Pezzotti, Bryan J. McEntire, Wenliang Zhu, C. Powell, Matteo Zanocco, J. Hendry, Elia Marin |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Polymers and Plastics Silicon chemistry.chemical_element 02 engineering and technology 010402 general chemistry Bone tissue 01 natural sciences Catalysis Biomaterials Metal chemistry.chemical_compound Colloid and Surface Chemistry Materials Chemistry medicine Cubic zirconia Ceramic 021001 nanoscience & nanotechnology 0104 chemical sciences Electronic Optical and Magnetic Materials medicine.anatomical_structure Silicon nitride chemistry Chemical engineering visual_art Physical vapor deposition visual_art.visual_art_medium 0210 nano-technology Stoichiometry |
| Zdroj: | Materials Today Chemistry. 19:100404 |
| ISSN: | 2468-5194 |
| DOI: | 10.1016/j.mtchem.2020.100404 |
| Popis: | Most structural bioceramics are comprised of metallic oxides such as alumina and zirconia. They are generally considered to be completely bioinert, but a non-oxide ceramic, silicon nitride, achieves equivalent levels of mechanical reliability while being bioactive. Silicon nitride can not only stimulate cellular proliferation but it is also antipathogenic with demonstrated efficacy against Gram-positive and Gram-negative bacteria, fungi, and viruses. In this work, three physical vapor deposition coatings with different Si:N ratios (silicon-rich, stoichiometric, and nitrogen-rich) were deposited on mirror-polished silica glass substrates. The coatings were characterized by spectroscopic and microscopic techniques and tested in vitro against E. coli and KUSA-A1 mesenchymal cells. Results showed that nitrogen-enriched SixNy has a strong antibacterial effect against E. coli and contributes to cellular proliferation while silicon-enriched SixNy stimulates the production of bone tissue, with higher indexes for mineralization and quality. These results suggest that SixNy's biological properties can be optimized for specific applications by carefully tuning its surface chemistry. |
| Databáze: | OpenAIRE |
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