ChemInform Abstract: The Isolation, Structure Determination and Cytotoxicity of the New Fungal Metabolite, Trichodermamide C

Autor:	James Longden, Rohan A. Davis, Vicky M. Avery, Peter Conrad Healy
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Fungal metabolite Chromatography Dipeptide chemistry High-content screening General Medicine Endophytic fungus Trichodermamide C Cytotoxicity Isolation (microbiology) Eupenicillium sp
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
Popis:	Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::098a85058dc7e49ea25930774c4ad048 https://doi.org/10.1002/chin.200839189 Zobrazit plný text záznamu Plný text