ChemInform Abstract: The Isolation, Structure Determination and Cytotoxicity of the New Fungal Metabolite, Trichodermamide C
Autor: | James Longden, Rohan A. Davis, Vicky M. Avery, Peter Conrad Healy |
---|---|
Rok vydání: | 2008 |
Předmět: | |
Zdroj: | ChemInform. 39 |
ISSN: | 1522-2667 0931-7597 |
Popis: | Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively. |
Databáze: | OpenAIRE |
Externí odkaz: |