Antibiotikatherapie bei operativen Intensivpatienten

Autor: Stefan Schröder, Berthold Bein, Marcel Hochreiter, T. Köhler, T. von Spiegel, A.-M. Schweiger, F. S. Keck
Rok vydání: 2008
Předmět:
Zdroj: Der Anaesthesist. 57:571-577
ISSN: 1432-055X
0003-2417
DOI: 10.1007/s00101-008-1379-x
Popis: The development of resistance by infective bacterial species is an incentive to reconsider the indications and administration of available antibiotics. Correct recognition of the indications and duration of therapy are particularly important for the use of highly potent substances in the intensive care situation. There has as yet been no clinical chemical parameter which is capable of specifically distinguishing a bacterial infection from a viral or non-infectious inflammatory reaction, but it now appears that procalcitonin (PCT) offers this possibility. The present study was intended to clarify whether PCT can be used to guide antibiotic therapy in surgical intensive care patients. A total of 110 patients in a surgical intensive care ward receiving antibiotic therapy after confirmed infection or a high grade suspicion of infection were enrolled in this study. In 57 of these patients a new decision was reached each day as to whether the antibiotic therapy should be continued after daily PCT determination and clinical assessment. The control group consisted of 53 patients with a standardized duration of antibiotic therapy over 8 days. Demographic and clinical data were comparable in both groups. However, in the PCT group the duration of antibiotic therapy was significantly shorter compared to controls (5.9+/-1.7 vs. 7.9+/-0.5 days, p
Databáze: OpenAIRE
Externí odkaz: