Metabolism of 3-amino-1,2,4-triazole in rats

Autor:	Chr. Böhme, W. Grunow, H. J. Altmann
Rok vydání:	1975
Předmět:	Chromatography Health Toxicology and Mutagenesis General Medicine Metabolism Urine Pharmacology Toxicology Excretion chemistry.chemical_compound Metabolic pathway chemistry Biotransformation Toxicity 3-Amino-1 2 4-triazole Feces
Zdroj:	Archives of Toxicology. 34:315-324
ISSN:	1432-0738 0340-5761
DOI:	10.1007/bf00353851
Popis:	3-Amino-1,2,4-triazole[5-14C] was administered orally to rats as a single dose of 50 mg/kg body weight. Excretion in urine and feces was followed during a period of 3 days. Within the first 24 hrs the main part of the radioactivity was found in the urine as unchanged amitrole. 3-Amino-5-mercapto-1,2,4-triazole and 3-amino-1,2,4-triazolyl-(5)-mercapturic acid were isolated from urine and identified by comparison with synthetic compounds. The total amount of these metabolites in the urine was about 6% of the dose. The metabolic pathways of amitrole and the possible relations between biotransformation and toxicity are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::097548e55946af51da3a4ba4529f93ae https://doi.org/10.1007/bf00353851 Zobrazit plný text záznamu Full text from SpringerLink