Abstract 455: Extracellular Matrix Incorporation of Thrombospondins Depends on Intermolecular Recruitment by Their L-lectin Domains: A Novel Process in ECM Organization

Autor:	Elena D Christofidou, Olga Stenina, Douglas R Keene, Josephine C Adams
Rok vydání:	2012
Předmět:	Cardiology and Cardiovascular Medicine
Zdroj:	Arteriosclerosis, Thrombosis, and Vascular Biology. 32
ISSN:	1524-4636 1079-5642
Popis:	Thrombospondins (TSPs) are conserved, multi-domain, extracellular glycoproteins, that participate in many biological processes. TSP1 is present in low levels in the extracellular matrix (ECM) of healthy vessel walls but is up-regulated during neointima and plaque formation. TSP1 is responsible for inducing vascular smooth muscle cell (VSMC) proliferation and migration upon vascular injury or during atherosclerosis. We have examined the organisation of elastic fibril layers in the aortae of 10 to 12-week old wild-type and Thbs1 -/- female and male mice. The total width of elastic layers was measured from medial cross sections of the ascending arch and thoracic aorta. 1055 measurements were made from Thbs1 -/- and 671 from wild-type sections. The total width of layers is increased in Thbs1 -/- mice (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::096e5d470bdf25ca0658fc3756cdddcb https://doi.org/10.1161/atvb.32.suppl_1.a455 Zobrazit plný text záznamu