Retracted: MicroRNA‐454 functions as an oncogene by regulating PTEN in uveal melanoma

Autor:	Xiang-Chun Gao, Shuyong Mi, Qiaoling Wang, Lei Sun, De-Jing Shi, Qing Han
Rok vydání:	2015
Předmět:	Oncogene biology Melanoma Biophysics Uveal Neoplasm Cell Biology Cell cycle medicine.disease_cause medicine.disease Biochemistry eye diseases Structural Biology microRNA Genetics Cancer research medicine biology.protein PTEN Ectopic expression Carcinogenesis Molecular Biology
Zdroj:	FEBS Letters. 589:2791-2796
ISSN:	1873-3468 0014-5793
DOI:	10.1016/j.febslet.2015.08.007
Popis:	MicroRNAs (miRNAs) regulate gene expression by targeted repression of transcription and translation, and are involved in carcinogenesis. In this study, we demonstrated that the expression of miR-454 was up-regulated in uveal melanoma tissues compared to normal tissues. Ectopic expression of miR-454 resulted in significant promotion of cell proliferation, colony formation, invasion and induction of cell cycle in uveal melanoma cells. Furthermore, we identified PTEN as a direct target of miR-454. Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR-454 in development of uveal melanoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::096acf859f07079c94b0e441b556a830 https://doi.org/10.1016/j.febslet.2015.08.007 Zobrazit plný text záznamu Plný text