The Knoevenagel condensation using quinine as an organocatalyst under solvent-free conditions
| Autor: | Kalpataru Das, Kavita Jain, Kuntal Pal, Saikat Chaudhuri |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Quinine
Solvent free Chemistry 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound Electrophile Materials Chemistry medicine Organic chemistry Knoevenagel condensation Methylene 0210 nano-technology medicine.drug |
| Zdroj: | New Journal of Chemistry. 43:1299-1304 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c8nj04219e |
| Popis: | The Knoevenagel condensation between active methylene compounds and aromatic carobonyl compounds has been developed using quinine as an organocatalyst to afford various electrophilic alkenes in excellent yields (up to 90%). In the presence of a catalytic amount of quinine (15 mol%), the reaction proceeded at room temperature (RT) under solvent-free conditions. In this green approach, the organocatalyst was recovered and recycled for up to four cycles without appreciable loss of activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|