Intralesional corticosteroid injection for intraosseous mandibular langerhans cell histiocytosis: A report of two cases
| Autor: | Caroline Robertsson, Lars Rasmusson, Johanna Ahlén Swartling, Carina Cardemil |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemotherapy
Pathology medicine.medical_specialty Myeloid business.industry medicine.medical_treatment Mandible 030206 dentistry medicine.disease Intralesional corticosteroid Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology Methylprednisolone Langerhans cell histiocytosis 030220 oncology & carcinogenesis Precursor cell Medicine Surgery Oral Surgery business Rare disease medicine.drug |
| Zdroj: | Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 33:599-604 |
| ISSN: | 2212-5558 |
| Popis: | Langerhans cell histiocytosis (LCH) is a rare disease characterized by inflammatory neoplastic proliferation by of myeloid precursor cells with a high affinity for bone and skin but may affect any organ. The clinical manifestation of LCH varies between single lesions that may show spontaneous resolvement to life-threatening multisystem disease. Treatments used are surgical interference, local radiotherapy, chemotherapy or sometimes a combination of these approaches. Intralesional injections of steroids have been described to have a good outcome in single skeletal lesions of LCH. This report presents two male patients, 6 and 9-years old, with LCH affecting the right posterior mandible. Both were successfully treated with intralesional injection of methylprednisolone in one single session. Complete recovery was confirmed clinically and radiographically approximately 2 years after injection. |
| Databáze: | OpenAIRE |
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