Zwitterionic-Type Molten Salt Catalyzed Iodination in Water: Synthesis of Iodoimidazoheterocycles
| Autor: | Susmita Mondal, Sadhanendu Samanta, Alakananda Hajra, Shubhanjan Mitra, Subhajit Mishra, Mukta Singsardar |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Organic Chemistry chemistry.chemical_element Regioselectivity Halogenation 010402 general chemistry Iodine 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Imidazole Surface modification Organic chemistry Molten salt Thiazole |
| Zdroj: | Synthesis. 48:4009-4015 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0035-1562492 |
| Popis: | An environmentally benign protocol for the iodination of imidazoheterocycles has been developed through sp2 C–H bond functionalization with molecular iodine in water at room temperature. The reaction is catalyzed by an imidazole-based zwitterion-type molten salt. A library of iodo-substituted imidazo[1,2-a]pyridines with broad functionality have been synthesized. This methodology is also applicable to imidazo[2,1-b]thiazole and imidazole scaffolds. |
| Databáze: | OpenAIRE |
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