Zur antiphlogistischen Wirksamkeit des Ginkgolids BN 52 021 bei der Verätzung des Kaninchenauges

Autor:	M. Tost, Ch. Taube, Hans-Gert Struck, H.-U. Block, H. Geiser, H.-J. Mest
Rok vydání:	1991
Předmět:	Chemotherapy medicine.medical_specialty business.industry medicine.medical_treatment Eye disease Chemical burn Antagonist Alpha (ethology) Radioimmunoassay Eye drop Pharmacology medicine.disease Anterior Eye Segment Ophthalmology medicine business
Zdroj:	Klinische Monatsblätter für Augenheilkunde. 199:278-282
ISSN:	1439-3999 0023-2165
DOI:	10.1055/s-2008-1046083
Popis:	BN 52 021, a specific antagonist of PAF receptors, was tested in the early-phase treatment of chemically burned eyes in 30 rabbits. The local application of BN 52 021 eyedrops-1% (water-soluble preparation, 5 times daily, in comparison with the other eye as a control) led to a visible anti-inflammatory effect (microscopically and macroscopically) of the chemically burned anterior eye segment. There was only a moderate increase of the concentration of PGF2 alpha after the chemical burn. The use of specific PAF antagonists seems to have a real chance for treatment of inflammatory reactions of the anterior eye segment. A combination with other mediator antagonists should be tested in further experiments.
Databáze:	OpenAIRE
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