Experimental Pharmacokinetics, Metabolism and Tissue Distribution Studies Fluorothiazinon, a of Novel Antivirulence Drug

Autor:	M. V. Savitskii, N. E. Moskaleva, N. A. Zigangirova, A. V. Soloveva, A. B. Sheremet, N. E. Bondareva, N. L. Lubenec, N. V. Pyatigorskaya, S. A. Appolonova
Rok vydání:	2023
Předmět:	General Medicine
Zdroj:	Journal Biomed. 19:73-84
ISSN:	2713-0428 2074-5982
DOI:	10.33647/2074-5982-19-1-73-84
Popis:	We studied the pharmacokinetics, tissue availability and metabolism of fluorothiazinon, a novel antivirulence drug, in mouse blood, liver, kidneys and lungs by administering the substance intragastrically at dose of 400 mg/kg. Fluorothiazinon was established to exhibit good tissue availability and long residential time. This drug is metabolized mainly by glucuronidation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::095364eded8b130343e3f580fe0c08cf https://doi.org/10.33647/2074-5982-19-1-73-84 Zobrazit plný text záznamu