Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera
| Autor: | J A Harp, B S Davis, S J Ewald |
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| Rok vydání: | 1984 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 133:10-15 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.133.1.10 |
| Popis: | The effects of Ly-5 alloantisera on the generation of cytotoxic T cells (CTL), on the effector phase of CTL killing, and on polyclonal mitogenesis were studied. Ly-5 antisera added at the beginning of mixed lymphocyte culture (MLC) suppressed the production of CTL in an allele-specific manner. Neither Ly-5.1 nor Ly-5.2 antisera inhibited the generation of cytotoxic effectors by Ly-5.1/Ly-5.2 heterozygous spleen cells; however, a combination of Ly-5.1 and Ly-5.2 antisera markedly suppressed the appearance of Ly-5 heterozygous CTL. Similarly, Ly-5 antisera inhibited the effector phase of CTL killing in an allele-specific manner. In addition, Ly-5 alloantisera specifically blocked concanavalin A and oxidative mitogenesis of splenocytes carrying the appropriate Ly-5 alloantigen. The results are discussed in light of a possible functional role of Ly-5 molecules in immune processes. |
| Databáze: | OpenAIRE |
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