| Popis: |
Compared to the widely used carbon-centered radicals, N-radicals have been relatively unexplored owing to the lack of practical and convenient production methods. Over the past few years, benefitting from the resurgence of reliable and controllable radical chemistry, N-radicals have been produced via thermal decomposition, oxidants, metal salts, or electrocatalysis. Therefore, numerous N-radical enabled cyclization of 1,n-enynes methods have been developed, providing a versatile and concise synthetic platform for the preparation of complex cyclic systems and natural products containing elaborate ring frameworks. In this review, we will summarize recent advances in the promising field of radical chemistry focusing on the production methods of N-radicals and their cyclization patterns, associated mechanisms, unmet challenges, and future opportunities. |
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