| Autor: |
José L. Capablo, Pedro Iñarrea, Nobuhide Ogihara, Jose R. Ara, E Mostacero, Jesús Martín, Cristina Iñiguez, Larrodé P, Hiroki Hirabayashi |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
The Open Spine Journal. 1:5-8 |
| ISSN: |
1876-5327 |
| Popis: |
Background: Evidence suggests that mitochondrial dysfunction and oxidative stress may be involved in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Some studies show the presence of altered anti-oxidative defence enzyme activity in the blood of ALS patients. It has also been demonstrated that a superoxide-dismutase-1 (SOD1) en- zyme fraction is located in the mitochondria. Objective: To Study the correlation between SOD1 activity and clinical data in ALS-patients. Patients and Methods: SOD1, SOD2 and aconitase activity was analysed in mitochondria of platelets from nine sporadic- ALS (SALS) patients and nine healthy-controls. The biochemical data was compared and correlated with clinical data from the ALS-patients. Results: Mitochondrial SOD1 activity was lower in ALS patients than in healthy controls, and much lower in more serious cases of ALS associated with respiratory insufficiency, weight-loss, low scores on the ALSFRS scale and the elderly. Conclusion: Mitochondrial SOD1 activity may be involved in the clinical evolution of SALS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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