A Perspective on the Development of Tandem Mass Spectrometry
Autor: | Christie G. Enke |
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Rok vydání: | 2016 |
Předmět: | |
DOI: | 10.1016/b978-0-08-043848-1.00026-2 |
Popis: | A tandem mass spectrometer involves two stages of mass analysis (MS1 and MS2) separated in time or space by a mass or charge-changing reaction, most often ion dissociation. The MS2 mass spectrum of the reaction products can provide a variety of information about the ions selected by MS1. Early MS/MS instruments were based on magnetic and electric sector mass analyzers with collisional dissociation energies in the kV range. Later MS/MS instruments used two quadrupole mass analyzers separated by an radio frequency-only quadrupole reaction chamber. Efficient low-energy fragmentation, coupled with inexpensive analyzers, brought `triple quadrupole' MS/MS into wide-spread adoption. Improvements in the instrumentation, including adaptation to emerging ionization technologies and wider areas of application, have ensured its continued popularity. |
Databáze: | OpenAIRE |
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