On the stereochemistry of the olefinic double bond in 13-membered heterocyclic rings accessible by ring-closing metathesis reaction

Autor:	P. Ratish Kumar, Shaik Rafi, C. Guravaiah, H. Surya Prakash Rao, Nandurka Muthanna
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Double bond Stereochemistry Organic Chemistry Heteroatom chemistry.chemical_element Ring (chemistry) Biochemistry Ruthenium chemistry.chemical_compound Ring-closing metathesis chemistry Drug Discovery Carbene
Zdroj:	Tetrahedron Letters. 53:6877-6880
ISSN:	0040-4039
Popis:	13-Membered heterocyclic ring analogs of the core structure of manzamine alkaloids were synthesized by ring closing metathesis (RCM) reaction. The influence of a remote heteroatom (N, O, S) on E/Z stereochemistry of the olefinic double bond formed in RCM reaction using Grubbs 1st and 2nd generation ruthenium carbene complexes was evaluated. Studies show that RCM reaction is kinetically controlled and the hetero atoms influence the double bond stereochemistry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::092d812dca6578f7181d75855f56cdb8 https://doi.org/10.1016/j.tetlet.2012.09.065 Zobrazit plný text záznamu Full Text from ScienceDirect