Oxidative stability of semi-solid excipient mixtures with corn oil and its implication in the degradation of vitamin A

Autor:	C. Barbé, Lyda Halbaut, C. de la Torre, M. Aroztegui
Rok vydání:	1997
Předmět:	Vitamin Chromatography Retinol Pharmaceutical Science Excipient Oxidative phosphorylation Dosage form chemistry.chemical_compound chemistry medicine Degradation (geology) Drug carrier Corn oil medicine.drug
Zdroj:	International Journal of Pharmaceutics. 147:31-40
ISSN:	0378-5173
DOI:	10.1016/s0378-5173(96)04789-8
Popis:	In this work the results obtained from studying accelerated oxidation of semi-solid excipient mixtures which contain corn oil, as vehicles for hard gelatin capsule filling, are compared with the oxidative degradation of vitamin A in the encapsulated formulations. In the first phase the Rancimat procedure was employed to evaluate the oxidation of the excipient mixtures in accelerated conditions, and in the second a real-time study was carried out on the encapsulated formulations using vitamin A as a model substance to test the oxidative resistance of the dosage form. The results show the influence of the percentage of corn oil and temperature storage on the stability of vitamin A and the relative effectiveness of BHA/BHT mixture. HPLC method was used for the quantitative determinations of vitamin A.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0915e268304851fdb5c9d60e625d23b7 https://doi.org/10.1016/s0378-5173(96)04789-8 Zobrazit plný text záznamu Full Text from ScienceDirect