The Effects of Long-Term Sustained Delivery of Dihydrotestosterone by Poly(lactic acid) Impregnated and Noncoated Biodegradable Ceramic Devices in Male Rodents
| Autor: | Barry G. England, Praphulla K. Bajpai, Hamed Benghuzzi |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Sustained delivery
medicine.medical_specialty Polymers and Plastics 0206 medical engineering Vas deferens Bioengineering 02 engineering and technology 021001 nanoscience & nanotechnology 020601 biomedical engineering Lactic acid Normal spermatozoa Biomaterials chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Dihydrotestosterone Internal medicine Materials Chemistry medicine Liberation ALCAP 0210 nano-technology Spermatogenesis medicine.drug |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 6:115-128 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/088391159100600201 |
| Popis: | The objectives of this investigation were to evaluate the release of dihydrotestosterone (DHT) from nonimpregnated and poly(lactic acid) (PLA) impregnated ALCAP ceramic reservoirs implanted in male rats, and to study the effects of delivered DHT on the reproductive system of male rats. A total of 120 Sprague-Dawley male albino rats were distributed equally into three groups. Two ALCAP capsules, one nonimpregnated and the other impregnated with PLA, were implanted in each rat in groups I and II. Capsules implanted in group I rats were loaded with 40 mg DHT each. Group II rats were implanted with two empty capsules (sham group), and group III animals served as un implanted controls. Eight rats from each group were euthanized at the end of the one, three, six, nine, and twelve months following the implantation of the ceramics. No significant changes in the weights of vital organs of rats were observed among any of the three different groups. Vas deferens and epididymal fluid were devoid of normal spermatozoa within three months of implanting the steroid-containing ceramics. Testes weights decreased significantly in the rats implanted with ALCAP ceramics containing DHT and the seminiferous tubules became oligospermic after one month and azoospermic after three months. The data collected in this study suggest that: (1) ALCAP ceramic cap sules are capable of delivering DHT for one year at a sustained manner; (2) DHT delivered by ALCAP capsules can be used effectively to regulate sperma togenesis in rats. |
| Databáze: | OpenAIRE |
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