In vivo agonist properties of 7-hydroxy-N,N-di-n-propyl-2-aminotetralin, a dopamine D3-selective receptor ligand
| Autor: | Amie Mazzola, Kelly Amy, Kenneth W. Rohrbach, William Keim, Kathryn A. Ward, John F. McElroy, James Cawley, Kim L. Zeller |
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| Rok vydání: | 1993 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Chemistry musculoskeletal neural and ocular physiology Pharmacology Dopamine agonist Dopamine receptor D1 Endocrinology Dopamine receptor Dopamine receptor D3 Internal medicine Dopamine receptor D2 Drug Discovery medicine Inverse agonist Endogenous agonist medicine.drug |
| Zdroj: | Drug Development Research. 30:257-259 |
| ISSN: | 1098-2299 0272-4391 |
| DOI: | 10.1002/ddr.430300409 |
| Popis: | The selective dopamine D3 receptor ligand 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) produced stereotypical sniffing and climbing, increased locomotor activity, and caused 6-hydroxydopamine-lesioned animals to rotate in a contralateral direction, behavioral effects highly predictive of dopamine agonist activity. In contrast, 7-OH-DPAT was inactive in the conditioned avoidance response, catalepsy, and anti-apomorphine test, animal models highly predictive of dopamine antagonist activity. These results indicate that 7-OH-DPAT is an agonist at dopamine receptors in vivo. © 1993 wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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