Synthesis of N-p-[di(2-chloroethyl)amino]phenacetylvalylmethionine diastereomers

Autor:	K. I. Karpavichyus, R. B. Klyukene, O. V. Kil'disheva
Rok vydání:	1976
Předmět:	chemistry.chemical_compound Methionine chemistry Stereochemistry Diastereomer Organic chemistry General Chemistry Enantiomer Racemization Carbodiimide
Zdroj:	Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 25:1950-1953
ISSN:	1573-9171 0568-5230
DOI:	10.1007/bf00921728
Popis:	1. A preparative method has been developed for obtaining diastereomers of N-p-[di(2-chloroethyl)-amino]phenacetylvalylmethionine from enantiomers of N-p-fdi(2-chloroethyl)amino]phenacetylvaline and the corresponding antipodes of methionine benzhydryl ester with the aid of N-ethoxycarbonyl-2-ethoxy-l-2-dihydroquinoline. 2. The synthesis of these diastereomers by the carbodiimide, mixed-anhydride and activated N-hydroxy-piperidyl ester methods is accompanied by appreciable racemization.
Databáze:	OpenAIRE
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