P655 Early life mebendazole exposure increases the risk of adult-onset ulcerative colitis: a population-based cohort study

Autor: M Agrawal, K Allin, A Iversen, S Mehandru, J F Colombel, T Jess
Rok vydání: 2022
Předmět:
Zdroj: Journal of Crohn's and Colitis. 16:i567-i568
ISSN: 1876-4479
1873-9946
DOI: 10.1093/ecco-jcc/jjab232.776
Popis: Background According to the hygiene hypothesis, exposure to parasites may promote immune tolerance and protect against inflammatory bowel disease (IBD). The early life period, considered to extend from prenatal life to up to 5 years of age, is important towards immune maturation; exposures during this period are especially relevant towards IBD risk. We examined the impact of exposure to mebendazole, a broad-spectrum anthelminthic agent, during childhood and adolescence, on the risk of IBD, ulcerative colitis (UC) and Crohn’s disease (CD). Methods We used prospectively collected historical data of all individuals born in Denmark between 1995 and 2018 from national registers to conduct a population-based cohort study. Using the National Prescription Register, we identified mebendazole exposure at Results Of 1,520,290 individuals in the cohort, 615,794 had childhood mebendazole exposure. 1,555 and 1,499 individuals were subsequently diagnosed with pediatric- and adult-onset IBD, respectively. On multivariable analysis, mebendazole exposure at Table: Crude and adjusted estimates for outcome with exposure to mebendazole in early life ( Figure: Cumulative incidence curves for (a) ulcerative colitis and (b) Crohn’s disease Conclusion Early life, but not later in childhood or adolescence, mebendazole exposure is associated with increase in the risk of adult-onset UC. Mebendazole exposure does not impact pediatric-onset IBD risk or CD risk. These findings emphasize the importance of early-life exposures in shaping the risk of IBD later in life, may indicate differences between UC and CD risk factors and pathways, and may call for re-evaluation of risks and benefits of large-scale helminth eradication programs.
Databáze: OpenAIRE