| Popis: |
INDOLE is a toxic compound produced in the intestine by the action of putrefactive bacteria on unabsorbed protein material. Upon absorption, however, it is readily converted to indican, a non-toxic product, and excreted through the kidney. The conversion occurs primarily in the liver. Five decades ago the capacity of this mechanism in the dog and rabbit was reported to be adequate in preventing any toxicity from normally absorbed indole (Hervieux, 1907). As far as can be ascertained in the literature, the degree of indole tolerance has not been determined for poultry. Changes in the number and kind of intestinal microorganisms following the feeding of antibiotics to chicks and poults have been reported by many investigators. Anderson et al. (1952), Romoser et al. (1952) and Sieburth et al. (1952) noted increases in E. coli and Proteus organisms both of which are noted indole formers. In rats, however, two Japanese workers (Makino … |
