Biological Activity of Low-Molecular Weight Dextran 40. The Effect on Serum Proteins, Plasma Blood Clotting Factors and Erythrocyte Sedimentation Rate
| Autor: | Ewa Kostrzewska, Witold Rudowski, Angela Naleçzyńska, Gregor A |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Biochemistry (medical) Biological activity Cell Biology General Medicine Fibrinogen Biochemistry Blood proteins In vitro chemistry.chemical_compound Low molecular weight dextran Dextran Blood clotting factors Endocrinology chemistry Erythrocyte sedimentation rate Internal medicine Medicine business medicine.drug |
| Zdroj: | Journal of International Medical Research. 1:194-203 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006057300100311 |
| Popis: | Dextran 40 infused in doses from 1.2 to 1.5 g/kg body weight decreases the concentration of proteins in the plasma and reduces the total amount of circulating protein. Dextran 40 in vitro precipitates high-molecular weight proteins participating in blood clotting, such as factor VIII and fibrinogen and, if infused, decreases their plasma levels. Addition in vitro of Dextran 40 to blood with a high ESR reduces the value proportionally to the concentration of dextran in the blood sample: after infusion of Dextran 40 the ESR decreases by a mean value of 19.9% after infusion of 500 ml and by 36.2% after 1000 ml. No bleeding was noted with these infusions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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