Betaine Supplementation Improves Beneficial Effects of Boxthorn (L ycium chinense Mill.) Leaf on Body Weight/Body Fat Increase and Plasma/Liver Triglycerides Accumulation in High-Fat Diet-Fed C57BL/6 Mice

Autor:	Moo Rim Kang, Chang Woo Lee, Myeong Youl Lee, Jong Soon Kang, Jieun Yun, Song-Hae Bok, Jung Hyu Shin, Ig Jun Cho, Won Kee Yoon, Eun Eai Kim, Sang-Bae Han, Soo Jin Oh
Rok vydání:	2014
Předmět:	Pharmacology C57BL/6 medicine.medical_specialty biology Biophysics food and beverages Cell Biology biology.organism_classification medicine.disease Obesity Management of obesity Transaminase chemistry.chemical_compound Lycium chinense Betaine Endocrinology chemistry Biochemistry Internal medicine Nonalcoholic fatty liver disease medicine Lycium Food Science
Zdroj:	Journal of Food Biochemistry. 38:620-626
ISSN:	0145-8884
DOI:	10.1111/jfbc.12099
Popis:	In the present study, we investigated the combinatorial effects of betaine supplementation and boxthorn (Lycium chinense Mill.) leaf on high-fat diet (HFD)-induced body weight/body fat increase, plasma lipid profile and liver damage. Suboptimal dosage of hot water extract of boxthorn leaf (Lycium chinense water extract, LWE) exerted partial inhibitory effect on body weight/body fat increase in HFD-fed mice. Betaine supplementation potentiated the effect of LWE showing a significant inhibition against HFD-induced increase in body weight/body fat. However, both LWE alone and LWE plus betaine had no effect on plasma cholesterols, including total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in HFD-fed mice. In contrast, HFD-induced increases in plasma and liver triglycerides were partially suppressed by LWE treatment and this was potentiated by betaine supplementation. In addition, both LWE alone and LWE plus betaine significantly suppressed HFD-induced glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase. Collectively, our results suggest that the combination of boxthorn leaf and betaine might be beneficial for the management of obesity and nonalcoholic fatty liver disease. Practical Applications For a long time, a combination of various substances was used to treat diseases effectively in traditional Chinese medicine. In the present study, we demonstrated that the supplementation of betaine synergizes with boxthorn leaf for improvement of high-fat diet-induced body weight/body fat increase and plasma/liver triglycerides accumulation. The results presented in this report suggest that the combination of boxthorn leaf and betaine might be beneficial for the treatment of obesity and related metabolic disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::08ee237750980af850d662048a2315c7 https://doi.org/10.1111/jfbc.12099 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.