Comparative evaluation of xylazine, detomidine, and medetomidine on cardiovascular biomarkers in dromedary camels
| Autor: | Fattah Iranmanesh, Amir Saeed Samimi, Omid Azari, Ehsanollah Sakhaee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
Detomidine Homocysteine 040301 veterinary sciences business.industry medicine.medical_treatment 04 agricultural and veterinary sciences Crossover study Medetomidine Pathology and Forensic Medicine 0403 veterinary science Xylazine chemistry.chemical_compound chemistry Lactate dehydrogenase Anesthesia Troponin I Medicine Anatomy business Saline medicine.drug |
| Zdroj: | Comparative Clinical Pathology. 29:337-340 |
| ISSN: | 1618-565X 1618-5641 |
| Popis: | This study was performed to comparatively evaluate cardiovascular effects of xylazine, detomidine, and medetomidine after intravenous (IV) administration in dromedary camels. Ten clinically and paraclinically healthy immature male dromedary camels aged 24 ± 2 months and weighing 200 ± 20 kg were used in this study. Camels were sedated with each of three treatments in a randomized, crossover design, with a minimum washout period of 8 days between treatments. Treatments were xylazine (0.4 mg kg−1), detomidine (50 μg kg−1), and medetomidine (20 μg kg−1). Camels in the control treatment were assigned to receive normal saline. Cardiovascular biomarkers were measured at baseline (T0), 2 h (T2), and 24 h (T24) after commencing the trial. Serum concentration of cardiac troponin I (cTnI) increased from baseline in detomidine treatment at 24 h after drug administration (P |
| Databáze: | OpenAIRE |
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