Scintigraphic Imaging of Endothelium-Dependent Vasodilation in the Forearm A Preliminary Report
| Autor: | Ozdes Emer, Mehmet Ozguven, Seyfettin Ilgan, Turgay Celik, Alper Ozgur Karacalioglu, Sait Demirkol, Selim Kilic |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
business.industry Sphygmomanometer Vasodilation General Medicine medicine.disease Blood pressure medicine.anatomical_structure Forearm Internal medicine Cuff Cardiology medicine Radiology Endothelial dysfunction Cardiology and Cardiovascular Medicine business Perfusion Flow-Mediated Vasodilation |
| Zdroj: | Circulation Journal. 70:311-315 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | Background The diagnosis of endothelial dysfunction has been gaining clinical importance, but although endothelial function testing is available in the research setting, no technique yet exists that is simple, safe, reproducible and easily performed as a clinical screening method. The aim of this study was to design a new, scintigraphic method of imaging the flow-mediated dilation in the forearm, which represents the functional characteristic of endothelial dysfunction. Methods and Results The study group comprised 118 subjects in whom left forearm ischemia was induced by inflating a sphygmomanometer cuff to supra systolic pressure for 4.5 min. Later, dynamic acquisition (2 s frame/min) was initiated after the injection of technetium-99m methoxy-isobutyl isonitril into the dorsal pedal veins. Equivalent regions of interest were drawn on both arms to detect total activity counts during 1 min and the perfusion ratios (left arm/right arm) were calculated. The left arm counts (22,203.3±12,372.7) were significantly higher than the right arm counts (9,980.9±5,931.9) (p |
| Databáze: | OpenAIRE |
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