Chiral aziridine ring opening: facile synthesis of (R)-mexiletine and (R)-phenoxybenzamine hydrochloride

Autor:	N. Viswanadh, Subramanian Jambu, M. Sasikumar, Murugan Muthukrishnan, R. Velayudham
Rok vydání:	2015
Předmět:	chemistry.chemical_compound chemistry Hydrochloride Stereochemistry Mexiletine Organic Chemistry Drug Discovery medicine Phenoxybenzamine Hydrochloride Aziridine Ring (chemistry) Biochemistry medicine.drug
Zdroj:	Tetrahedron Letters. 56:5269-5271
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2015.07.032
Popis:	A simple and efficient synthesis of chiral drugs (R)-mexiletine 1, an anti-arrhythmic drug and (R)-phenoxybenzamine hydrochloride 2, an anti-hypertensive drug has been described via controlled reductive ring opening of chiral aziridine as a key step. The target compounds 1 and 2 were obtained in overall yields of 34% and 10.5%, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::08d817ce33daaec0c782d0b34de0f21d https://doi.org/10.1016/j.tetlet.2015.07.032 Zobrazit plný text záznamu Full Text from ScienceDirect