Expression of somatostatin and dopamine receptors in ACTH-producing tumours

Autor:	Iu A Ablitsov, N P Goncharov, Anastasia M. Lapshina, A Iu Abrosimov, Ivan Ivanovich Dedov, N S Kuznetsov, Svetlana Arapova, Marova Ei, L Ia Rozhinskaia, A Iu Grigor'ev
Rok vydání:	2010
Předmět:	endocrine system medicine.medical_specialty Kidney Pathology Lung Somatostatin receptor Endocrinology Diabetes and Metabolism Biology medicine.disease medicine.anatomical_structure Somatostatin Endocrinology Dopamine receptor Internal medicine medicine Carcinoma Carcinoid tumour
Zdroj:	Problems of Endocrinology. 56:14-18
ISSN:	2308-1430 0375-9660
DOI:	10.14341/probl201056114-18
Popis:	This study was designed to compare immunoexpression of somatostatin receptors (SR)1-5 and dopamine receptors 2 (DR2) in pituitary and non-pituitary ectopic ACTH-producing tumours. A total of 35 patients were enrolled in the study including 21 with Cushing's disease (CD) and 14 with ACTH-ectopic syndrome (ACTH-ES) associated with carcinoid tumours of lungs (n=11), kidney (n=1), thymus (n=1) and with small-cell lung carcinoma (n=1). All patients with corticotropinomas exhibited expression of SR 1-5 dominated by SR-1 (57%). 81% of these tumours expressed two and more SR subtypes. DR2 expression was documented in 52% of the tumours and co-expression of DR2 with different SR subtypes in 29%. Neoplasms associated with ACTH-ES expressed SR with the predominance of SR-3 (72%). Half of these tumours co-expressed two and more SR subtypes. Expression of DR2 was demonstrated in 50% of the neoplasms associated with ACTH-ES; 38% of them co-expressed SR and DF2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::08c870fb87350ba98601cd727353b9bd https://doi.org/10.14341/probl201056114-18 Zobrazit plný text záznamu