Introduction to the Theme 'New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development'
Autor: | Terrence F. Blaschke, Urs A. Meyer, Susan G. Amara, Paul A. Insel |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pharmacology Drug Cognitive science Opioid epidemic Drug discovery media_common.quotation_subject Biology Toxicology Precision medicine Bioinformatics 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Action (philosophy) chemistry media_common Toxicant Theme (narrative) |
Zdroj: | Annual Review of Pharmacology and Toxicology. 58:33-36 |
ISSN: | 1545-4304 0362-1642 |
DOI: | 10.1146/annurev-pharmtox-092617-121952 |
Popis: | The theme “New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development” links 13 articles in this volume of the Annual Review of Pharmacology and Toxicology (ARPT). The engaging prefatory articles by Arthur Cho and Robert Lefkowitz set the stage for this theme and for the reviews that insightfully describe new approaches that advance research and discovery in pharmacology and toxicology. Examples include the progress being made in developing Organs-on-Chips/microphysiological systems and human induced pluripotent stem cell–derived cells to aid in understanding cell and tissue pharmacokinetics, action, and toxicity; the recognition of the importance of circadian rhythm, the microbiome, and epigenetics in drug and toxicant responses; and the application of results from new types of patient-derived information to create personalized/precision medicine, including therapeutics for pain, which may perhaps provide help in dealing with the opioid epidemic in the United States. Such new information energizes discovery efforts in pharmacology and toxicology that seek to improve the efficacy and safety of drugs in patients and to minimize the consequences of exposure to toxins. |
Databáze: | OpenAIRE |
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