Synthetic Routes to Isomeric Imidazoindoles by Regioselective Ring‐Opening of Activated Aziridines Followed by Copper‐Catalysed C–N Cyclization

Autor:	Deo Prakash Tiwari, Masthanvali Sayyad, Manas K. Ghorai, Imtiyaz Ahmad Wani
Rok vydání:	2017
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Regioselectivity chemistry.chemical_element 010402 general chemistry Ring (chemistry) 01 natural sciences Medicinal chemistry Copper Domino 0104 chemical sciences Structural isomer Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2017:2369-2378
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.201700267
Popis:	Two new synthetic routes that deliver substituted imidazoindoles in high yields with excellent ee values have been developed. The reactions proceed through ring-opening of activated aziridines with 2,2-dibromovinylanilines or 2-bromoindoles, followed by a Cu-catalysed domino C–N,C–N-cyclization, or a C–N cyclization, respectively. The first route gives rise to one regioisomer, and the second route gives the other.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::08c2f4570e82477dbc34c056e1d661bb https://doi.org/10.1002/ejoc.201700267 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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