The metabolism of 4-methylheptane in male Fischer 344 rats
| Autor: | D.D. Bombick, M.Paul Serve, D. R. Mattie, J.Matthew Clemens, Gayle A. McDonald, Theresa M. Rezek |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Kidney
Environmental Engineering Chromatography Health Toxicology and Mutagenesis Urinary system Public Health Environmental and Occupational Health General Medicine General Chemistry Metabolism Mass spectrometry Pollution Acetic acid chemistry.chemical_compound medicine.anatomical_structure chemistry Toxicity medicine Environmental Chemistry Gas chromatography Hyaline |
| Zdroj: | Chemosphere. 28:1571-1579 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(94)90416-2 |
| Popis: | The urinary metabolites of 4-methylheptane (4-MH) in male Fischer 344 rats, after administering the hydrocarbon by gavage, included 6-hydroxy-4-methyl-2-heptanone, 4-methyl-3,5-heptanediol, di-n-propyl acetic acid, 4-methyl-2,5-heptanediol, 2-methyl-3-hydroxy-1-pentanoic acid, 4-methyl-1-heptanoic acid, 4-methyl-1,4-heptanediol, 4-methyl-2,6,-heptanediol and 4-methyl-1,6-heptanediol. Metabolism strongly favored the formation of diols and carboxylic acids. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Histopathologic examination of the kidneys revealed minimal hyaline droplet formation (α2u-globulin nephropathy) in the proximal tubule area. |
| Databáze: | OpenAIRE |
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