Three-component condensation of 5-aminoimidazole derivatives with aldehydes and Meldrum’s acid. Synthesis of 3,4,6,7-tetrahydroimidazo[4,5-b]pyridin-5-ones

Autor:	Boris V. Lichitsky, M. M. Krayushkin, Andrey N. Komogortsev, A. A. Dudinov
Rok vydání:	2012
Předmět:	chemistry.chemical_compound 5-aminoimidazole chemistry Decarboxylation Condensation Organic chemistry General Chemistry Alkaline hydrolysis (body disposal) Meldrum's acid Sodium salt
Zdroj:	Russian Chemical Bulletin. 61:1591-1595
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-012-0211-6
Popis:	A convenient method for the synthesis of the earlier unknown substituted 3,4,6,7-tetrahydroimidazo[4,5-b]pyridin-5-ones was developed based on a three-component condensation of 5-aminoimidazole derivatives, aldehydes, and Meldrum’s acid. Unstable aminoimidazole derivatives were readily formed in situ by decarboxylation of 5-amino-4-imidazolecarboxylic acids in acidic medium at room temperature, whose sodium salts were obtained by the alkaline hydrolysis of the corresponding, readily available esters.
Databáze:	OpenAIRE
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