Corneal confocal microscopy is efficient, well-tolerated, and reproducible

Autor:	Blaine Allen, A. Smith, Margaret Koach, Michael T. Porzio, Kathleen B. Digre, Gene Kim, Bonnie M. Keung, Mark D. Mifflin, J. Singleton
Rok vydání:	2013
Předmět:	medicine.medical_specialty Reproducibility Microscope genetic structures Intraclass correlation business.industry General Neuroscience Retinal Nerve fiber Anatomy eye diseases law.invention chemistry.chemical_compound medicine.anatomical_structure chemistry law Confocal microscopy Ophthalmology Cornea medicine sense organs Neurology (clinical) Tomography business
Zdroj:	Journal of the Peripheral Nervous System. 18:54-58
ISSN:	1085-9489
DOI:	10.1111/jns5.12008
Popis:	In order to develop an efficient, reproducible, and well-tolerated protocol for assessing corneal innervation, 11 normal subjects underwent corneal confocal microscopy (CCM) using a Heidelberg Retinal Tomography III microscope. Five standardized locations were sampled in the left eye and one centrally in the right. The protocol was repeated 1–4 weeks later. A blinded technician measured nerve fiber length (NFL) and tortuosity coefficient (TC). The relationship between image location and NFL and TC was assessed using one-way analysis of variance, and reproducibility determined using relative intertrial variability and intraclass correlation coefficients. NFL reproducibility was maximized by averaging four or more images from the left eye, or one central image from both eyes. TC was less reproducible. CCM is a rapid, well-tolerated, and reproducible method for assessing corneal innervation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0887b960b2ec0c2729de27d180a18e67 https://doi.org/10.1111/jns5.12008 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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