Amino Derivatives of Natural Epoxyalantolactone: Synthesis and Cytotoxicity toward Tumor Cells

Autor:	S. A. Pukhov, Lada V. Anikina, Sergey G. Klochkov, E. S. Dubrovskaya, S. V. Afanasyeva, A. V. Semakov
Rok vydání:	2018
Předmět:	010405 organic chemistry Chemistry Organic Chemistry medicine.disease_cause 01 natural sciences Biochemistry In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry Apoptosis medicine Bioorganic chemistry Cytotoxic T cell Signal transduction Cytotoxicity Oxidative stress Conjugate
Zdroj:	Russian Journal of Bioorganic Chemistry. 44:553-561
ISSN:	1608-330X 1068-1620
Popis:	Reactions of natural epoxyalantolactone with primary and secondary amines, which lead to hydrated benzo[g]furo[4,3,2-cd]indolones and eudesmane-type amino derivatives, respectively, have been studied. Epoxyalantolactone conjugates have been synthesized with the involvement of pharmacophoric amines, and their cytotoxic activity toward some tumor cell lines has been tested. The involvement of the signaling pathway of protein p53 in the death of tumor cells, the contribution of oxidative stress, and the induction of apoptosis have been investigated in experiments in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::08820b3430d12b2d62425928e27a6875 https://doi.org/10.1134/s1068162018040155 Zobrazit plný text záznamu Full text from SpringerLink